Reshma's first introduction to American TV audiences was a guest appearance in 30 Rock season 2 episode 8, "Secrets and Lies" as a party attendant. Her first major role was on the USA Network TV show Royal Pains were she played ambitious and knowledgeable P.A. (physician's assistant) Divya Katdare from 2009 to 2016. Shetty currently resides in New York City, where they shot parts of Royal Pains. Shetty is married to actor Deep Katdare who starred with her in the Broadway production Bombay Dreams. She married him on March 19, 2011. She gave birth to their daughter, Ariya Eliana, on October 6, 2015.